Welcome to UKDcure

Uromodulin Kidney Disease (UKD) is an inherited kidney disease that often causes gout early in life, and leads to kidney failure later in life. It is caused by mutations (changes) in the UMOD gene, which is the gene that contains the instructions to make a protein called uromodulin. Anyone who has one of these UMOD gene mutations will have UKD, and their children will have a 50% chance of having UKD.

UKD is also known by many other names including:

  • Familial Juvenile Hyperuricemic Nephropathy type 1 (FJHN1)
  • Medullary Cystic Kidney Disease type 2 (MCKD2)
  • Uromodulin Associated Kidney Disease (UAKD & UMAK)

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